The article presents the results of many years of studies of the Upper Cretaceous and Paleogene sediments in the territory of West Siberian Plain. The heterogeneous structure of these sediments in different regions of the plain is shown. The lithological and palynological characteristics of a number of studied wells driiled in diiferent years in Omsk and Kulunda Depressions, in Baraba Lowland and Bakchar Basin are given. The obtained palynological data allowed to substantiate the age of the deposits and to make suggestions concerning their depositional environment, and to clarify the subdivision of geological section into formations. The sections of the Upper Cretaceous and Paleogene deposits in diiferent lithofacial regions of the Western Siberia diifer from each other in completeness, genesis, and paleontological characteristics. The Upper Cretaceous sediments in Western Siberia are represented by formations of both marine (Pokur, Kuznetzovo, Ipatovo, Slavgorod and Gan'kino Formations) and continental genesis (Lenkovo and Sym formations). The Paleogene sediments, with the exception of Oligocene, mostly have a marine genesis-these are Talitsa-, Marsyat-, Lulinvor-, Tavda- and Yurki formations, but there are also continental sediments ( Ostrovnoje Formation). A large stratigraphic break in the Upper Cretaceous and Paleogene boundary deposits, covering a significant part of the Maastrichtian, Paleocene, Ypresian, and Lutetian stages of the Eocene, was established in the southeast of the West Siberian Plain (Bakchar Basin, Baraba Lowland and Kulunda Depression). The most complete sections are located in the Omsk Depression, where the Upper Cretaceous Gan'kino Formation is covered by Talitsa and Lulinvor Formations of Paleogene age. The most important events occurring at the boundary of the Cretaceous and Paleogene in Western Siberia can be traced currently in a few sections located in the Trans-Ural area, since there was no sedimentation in the rest of the territory at that time.